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The pigment pheomelanin gives red hair its distinctive color.

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Red hair has far more of the pigment pheomelanin than it has of the dark pigment eumelanin. The genetics of red hair, discovered inappear to be associated with the melanocortin-1 receptor MC1Rwhich is found on chromosome Red hair is associated with fair skin color because low concentrations of eumelanin throughout the body of those with red hair caused by a MC1R mutation can cause both.

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The lower melanin concentration in skin confers the advantage that a sufficient concentration of important Vitamin D can be produced under low light conditions.

However, when UV-radiation is strong as in regions close to the equator the lower concentration of melanin leads to several medical disadvantages, such as a higher risk of skin cancer. The MC1R recessive variant gene that gives people red hair generally results in skin that is unable to tan. Because of the natural tanning reaction to the sun's ultraviolet light and high amounts of pheomelanin in the skin, freckles are a common but not all-inclusive feature of red-haired people.

Eighty percent of redheads have an MC1R gene variant. If one of these changes is present on both chromosomes then the respective individual is likely to have red hair. This type of inheritance is described as an autosomal recessive mode of inheritance.

Even if both parents do not have red hair themselves, both can be carriers for the gene and have a redheaded child. Genetic studies of dizygotic fraternal twins indicate that the MC1R gene is not solely responsible for the red hair phenotype; unidentified modifier genes exist, making variance in the MC1R gene necessary, but not always sufficient, for red hair production.

Evolution Origins Red hair is the rarest natural hair color in humans.

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The non-tanning skin associated with red hair may have been advantageous in far-northern climates where sunlight is scarce. Studies by Bodmer and Cavalli-Sforza hypothesized that lighter skin pigmentation prevents rickets in colder climates by encouraging higher levels of vitamin D production and also allows the individual to retain heat better than someone with darker skin.

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In Africa, for example, red hair is selected against because high levels of sun harm untanned skin. However, in Northern Europe this does not happen, so redheads can become more common through genetic drift.

Disappearing blonde gene A report in The Courier-Mailwhich cited the National Geographic magazine and unnamed "geneticists", said that red hair is likely to die out in the near future.

The National Geographic article in fact states "while redheads may decline, the potential for red isn't going away". It is not likely to disappear at any time in the foreseeable future. Studies have shown that red hair alleles in MC1R increase freckling and decrease tanning ability. Sunshine can both be good and bad for a person's health and the different alleles on MC1R represent these adaptations. It also has been shown that individuals with pale skin are highly susceptible to a variety of skin cancers such as melanomabasal cell carcinomaand squamous cell carcinoma.

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One study found that people with red hair are more sensitive to thermal pain associated with naturally occurring low vitamin K levels[50] while another study concluded that redheads are less sensitive to pain from multiple modalities, including noxious stimuli such as electrically induced pain.

A study showed women with red hair had a greater analgesic response to that particular pain medication than men. Both derive from the same precursor molecule, POMCand are structurally similar. Melanocyte-stimulating hormone normally stimulates melanocytes to make black eumelaninbut if the melanocytes have a mutated receptor, they will make reddish pheomelanin instead.

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There is little or no evidence to support the belief that people with red hair have a higher chance than people with other hair colors to hemorrhage or suffer other bleeding complications. However, in rare cases red hair can be associated with disease or genetic disorder: In cases of severe malnutritionnormally dark human hair may turn red or blonde. The condition, part of a syndrome known as kwashiorkoris a sign of critical starvation caused chiefly by protein deficiency, and is common during periods of famine.

One variety of albinism Type 3, a. Portrait of a Lady, ca. In Anne of Green Gablesa character says of Anne Shirleythe redheaded heroine, that "her temper matches her hair", while in The Catcher in the RyeHolden Caulfield remarks that "People with red hair are supposed to get mad very easily, but Allie [his dead brother] never did, and he had very red hair. Another belief is that redheads are highly sexed; for example, Jonathan Swift satirizes redhead stereotypes in part four of Gulliver's Travels"A Voyage to the Country of the Houyhnhnms ," when he writes that: This leads some to associate red hair with youthfulness, a quality that is generally considered desirable.

In several countries such as IndiaIranBangladesh and Pakistanhenna and saffron are used on hair to give it a bright red appearance. The hair color " Titian " takes its name from the artist Titianwho often painted women with red hair. A savage red-haired man is portrayed in the fable by Grimm brothers Der Eisenhans as the spirit of the forest of iron.

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